Propantheline bromide
Pro-banthine (propantheline bromide) is a small molecule pharmaceutical. Propantheline bromide was first approved as Pro-banthine on 1982-01-01. It is used to treat irritable bowel syndrome, pancreatitis, peptic ulcer, spasm, and urethral diseases amongst others in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M2. In addition, it is known to target muscarinic acetylcholine receptor M4.
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urolithiasis | D052878 | — | N20-N23 | — | — | — | 1 | — | 1 |
| Urinary calculi | D014545 | — | N20.9 | — | — | — | 1 | — | 1 |
| Calculi | D002137 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 1 | — | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Propantheline bromide |
| INN | propantheline bromide |
| Description | Propantheline bromide is a member of xanthenes. |
| Classification | Small molecule |
| Drug class | Antimuscarinic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc2ccccc21)C(C)C.[Br-] |
Identifiers
| PDB | — |
| CAS-ID | 50-34-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1240 |
| ChEBI ID | — |
| PubChem CID | 9279 |
| DrugBank | DB00782 |
| UNII ID | UX9Z118X9F (ChemIDplus, GSRS) |
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CHRM3
CHRM3
CHRM1
CHRM1
CHRM2
CHRM2
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48 adverse events reported
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